Expression of bone morphogenetic protein-2 in the rostral migratory stream in developing rat brain
- VernacularTitle:骨形态发生蛋白-2在大鼠脑内嘴侧迁移流中的发育学表达
- Author:
Liu JIAN-JUN
1
;
Yao ZHONG-XIANG
;
Zou LI-YUN
;
Chen XING-SHU
;
Cai WEN-QIN
;
Yang HUI
Author Information
1. 第三军医大学
- Keywords:
BMP-2;
neural stem cell;
rostral migratory stream;
expression
- From:
Neuroscience Bulletin
2005;21(6):371-375
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expressional pattern of bone morphogenetic protein-2 (BMP-2) in rostral neural stem cells migratory stream at different time in developing rat brain. Methods To examine the expression of BMP-2 by reverse transcriptase-polymerase chain reaction (RT-PCR) and immunohistochemisyry. Results BMP-2 were expressed in all the SVZa, RMS and OB areas in rat brain at different developmental stages. The expression level of BMP-2 mRNA is not very high. (1) The expression level of BMP-2 were obvious highest at the E14 than at the P0 and P7, and there are lowest at P7 at the same location; (2) the expression level of BMP-2 were higher at OB and SVZa than at RMS at same developing stage. Conclusion The spatial-temporal expressional pattern of BMP-2 in SVZa, RMS and OB of rat brain indicates that BMP-2 maybe is an important factor regulating the proliferation, migration and differentiation of NSCs derived from SVZa.
