Advances on P-glycoprotein at blood-brain barrier
- VernacularTitle:血脑屏障上P-糖蛋白研究进展
- Author:
Lu YING
1
;
Hong HAO
;
Liu GUO-QING
Author Information
1. China Pharmaceutical University
- Keywords:
P-glycoprotein;
blood-brain barrier;
transporter;
multidrug resistance
- From:
Neuroscience Bulletin
2005;21(5):351-355
- CountryChina
- Language:Chinese
-
Abstract:
P-glycoprotein is an important drug efflux transporter at the blood-brain barrier. It is involved in various physiological and pathological processes in the body and can change the kinetic behavior of drugs in the brain. This article reviews the recent advances of P-glycoprotein on the blood-brain barrier, which is helpful for us to understand some diseases of the central nervous system, devise their therapeutic regimens and develop new regulator of P-glycoprotein.
