Blood-brain barrier-morphology, modulation and clinical implications
- VernacularTitle:血脑屏障--形态、调节和临床意义
- Author:
Liu YE
1
;
Guan YANG-TAI
Author Information
1. Shanghai Changhai hospital, Second Military Medical University
- Keywords:
blood-brain barrier;
regulation;
ultrastructure;
clinical implications
- From:
Neuroscience Bulletin
2005;21(5):344-350
- CountryChina
- Language:Chinese
-
Abstract:
The blood-brain barrier (BBB) provides both anatomical and physiological protection for the central nervous system ( CNS), strictly regulating or impeding the entry of many substances and blood-borne cells into the nervous tissue. Three cellular elements of the brain microvasculature compose the BBB-endothelial cells, astrocyte end feet, and perivascular cells (PCs). Tight junctions (TJs) , present between the cerebral endothelial cells, form a diffusion barrier, which is a very important part of BBB. The astrocytes and other cells can release chemical factors that modulate endothelial permeability. Dysfunction of the BBB, for example, impairment of the TJ seal, complicates a number of neurological diseases including stroke, infection, brain tumor, multiple sclerosis and Alzheimer disease. We review here the recent developments in our understanding of the BBB and the role of BBB dysfunction in CNS diseases.
