Influence of paraquat on dopamine transporter mRNA and vesicular monoamine transporter2 mRNA in the nigrostriatum of paraquat induced Parkinsonian mice
- VernacularTitle:百草枯干预不同时间后DAT和VMAT2基因表达的时程变化
- Author:
Ren JIN-PENG
1
;
Ren HUI-MIN
;
Jiang YU-PING
Author Information
1. Huashan Hospital affiliated to Fudan University
- Keywords:
Parkinson disease;
paraquat;
dopamine transporter (DAT);
vesicular monoamine transporter2 (VMAT2)
- From:
Neuroscience Bulletin
2005;21(5):330-334
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of time-course of dopamine transporter (DAT) mRNA and vesicular monoamine transporter2 (VMAT2) mRNA in the substantia nigra of Parkinsonian mice induced by paraquat orally. Methods RT-PCR technique was used to detect the changes of expressions of DAT and VMAT2 mRNA in the substantia nigra of mice after paraquat taken orally for different days. Results The gene expressions of DAT and VMAT2 were decreased gradually two weeks after paraquat. Conclusion In the early stage of paraquat-induced parkinsonian mice, the expressions of DAT and VMAT2 mRNA were decreased, and the degree of reduced expression was more severe with the development of Parkinson disease. DAT and VMAT2 may be involved in the pathogenesis of Parkinson disease.
