A pilot study of procedural learning in patients with non-demented Parkinson's disease
- VernacularTitle:帕金森病患者程序性学习的初步研究
- Author:
Wang XIAO-PING
1
;
Zhao YONG-BO
;
Lassonde M
;
Geng CHANG-MING
Author Information
1. 上海交通大学附属第一人民医院
- Keywords:
Parkinson's disease;
implicit and explicit memory;
cognition;
procedural learning
- From:
Neuroscience Bulletin
2005;21(4):291-295
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study memory changes in patients with non-demented Parkinson' s disease (PD) without depression. Methods The Nissen Version (serial reaction time task, SRTT) software, as a task of procedural learning, along with the WMS-CR and two tasks of implicit memory were used in 16 PD patients( Hoehn-Yahr score Ⅰ - Ⅱ degrees)and normal controls enrolled. Results In the explicit WMS-CR and the implicit (word stem completion and degraded picture naming) tasks, the patients' scores fell within normal limits. In the SRTT, controls displayed significantly reduced response times and error rates across blocks of repeated sequence trials. By contrast, PD patients only showed a reduction in error rates but no change in response times. Conclusion Impairment of nigrostriatal pathway selectively affects performance in visuo-motor learning tasks such as the SRTT, but not in the explicit tasks of WMS-CR, and the implicit tasks such as word stem completion and degraded picture naming, supporting the multiple memory theory.
