Nogo-A immunoreactivity in injured spinal cord of adult rats
- VernacularTitle:大鼠脊髓损伤后Nogo-A表达变化的免疫组织化学研究
- Author:
Guo QIANG
1
;
Li SHU-RONG
;
Su BING-YIN
Author Information
1. 第三军医大学
- Keywords:
spinal cord injury;
CNS regeneration;
Nogo-A;
immunohistochemistry;
rat
- From:
Neuroscience Bulletin
2005;21(4):287-290
- CountryChina
- Language:Chinese
-
Abstract:
Object To study the changes of Nogo-A expression after the spinal cord injury in rats. Methods The rats were divided into the spinal cord injured group, the sham operation group and the normal control group, respectively. 1 d,3 d and 7 d after the operation, the Nogo-A immunohistochemistry was performed. Results Nogo-A was expressed obviously by the neurons and oligodendrocytes. With the survive time increasing, the relative intensity of immunoreactivity and the number of Nogo-A positive neurons and oligodendrocytes were both decreased after an initial increase. Conclusion Nogo-A is expressed by neurons after the spinal cord injury. The expression of Nogo-A and the number of positive neurons in grey matter and oligodendrocyte-like cells in white matter are increased obviously at first, and then decreased gradually.
