Role of cortical and hippocampal nNOS protein in memory deficits induced by sleep deprivation in rats
- VernacularTitle:睡眠剥夺大鼠大脑皮层和海马 nNOS表达的改变在其学习记忆损伤中的作用
- Author:
Chen JUN
1
;
Li JI-SHENG
;
Wang HUA-REN
;
Zhang HENG
Author Information
1. 武警医学院
- Keywords:
sleep deprivation;
memory;
neuronal nitric oxide synthase;
rat
- From:
Neuroscience Bulletin
2005;21(4):283-286
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the changes of learning and memory as well as neuronal nitric oxide synathase (nNOS) in cortex and hippocampus of rats after sleep deprivation (SD). Methods SD was induced in male Wistar rats by employing "flower pot" technique. The performance in Y maze and the number of nNOS positive neurons in cortex and hippocampus after different time of SD were measured. Results ( 1 ) The correct rates of Y maze test were 24.3%,17.6%, 41.9% less in 3 SD groups than CC group(P ＜0.01 ). (2) The number of nNOS positive neurons in cortex was 8.7% more in SD1d group than CC group(P ＜0.01 ); but 9.0% and 16.0% less in SD2d group and SD3d group than CC group(P ＜0.01). In hippocampal CA1 sector, nNOS positive neurons of the 3 SD groups were 9.4%, 16.0% and 22.0% less in number respectively than CC group. Conclusion SD induces the expression of changes nNOS protein in cortex and hippocampal CA1 and thereby impairs learning and memory in rats.
