The role of caspase and calpain in neuronal apoptosis and pathogenesis of Huntington disease
- VernacularTitle:Caspase和calpain在神经元凋亡和亨廷顿舞蹈病发病机制中的作用
- Author:
Wang YAN
1
;
Gu ZHEN-LUN
;
Qin ZHENG-HONG
Author Information
1. Soochow University School of Medicine
- Keywords:
caspase;
calpain;
Huntington disease;
huntingtin;
apoptosis;
neurodegenerative disorders
- From:
Neuroscience Bulletin
2005;21(3):224-229
- CountryChina
- Language:Chinese
-
Abstract:
Huntington disease (HD) is a neurodegenerative disorder caused by an expansion of the polyglutamine tract in the N-terminal huntingtin (Htt). Htt is a substrate of caspases and calpains, the proteases involved in initiation and execution of neuronal apoptosis. Caspase- and calpain-mediated cleavage of mutant Htt results in the production of toxic Nterminal Htt fragments. Recent studies suggest that Htt cleavage may be a crucial step in the pathogenesis of HD and may be a potential molecular target for HD therapy.
