Effects of insulin therapy on alterations of learning and memory functions and concentrations of somatostatin and vasoactive intestinal peptide in frontal cortex and hippocampus of diabetic rats
- VernacularTitle:胰岛素治疗对糖尿病大鼠学习记忆功能障碍及大脑皮层额叶和海马神经肽含量变化的影响
- Author:
Guan QING-BO
1
;
Han HUI
;
Dong JIAN-JUN
;
Jiang LING
;
Zhao WEN-BO
;
Zhao JIA-JUN
;
Wang GUI-LAN
Author Information
1. Shandong Province Hospital
- Keywords:
cognitive function;
somatostatin;
vasoactive intestinal peptide;
diabetes mellitus;
insulin
- From:
Neuroscience Bulletin
2005;21(3):215-218
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of insulin therapy on alterations of learning and memory functions and somatostatin (SS) and vasoactive intestinal peptide (VIP) levels in frontal cortex and hippocampus of diabetic rats. Methods The diabetic rat models were produced by injection with 1% streptozotocin, followed by insulin administration. The water maze test was used to verify the changes of learning and memory functions of the rats and radioimmunoassary was carried out to observe the alterations of SS and VIP levels in the cerebral cotex and hippocampus. Results The swimming time of untreated diabetic rats in water maze was prolonged significantly and the successful frequencies decreased significantly in comparison to those of controls. The contents of SS reduced significantly both in the frontal cortex and hippocampus of untreated diabetic rats, while VIP were not changed. The changes in learning and memory functions and SS levels in insulin-treated diabetics were not significantly different from those of controls. Conclusion The cognitive dysfunctions induced by diabetes may be correlated with the decrease of SS and alleviated with insulin administration.
