Changed expression of high-affinity neurotrophin receptors on trigeminal motoneurons following masseteric nerve transection in the rat
- VernacularTitle:大鼠咬肌神经切断后三叉神经运动神经元高亲和性神经营养因子受体表达的变化
- Author:
Zhang FU-XING
1
;
Pang YOU-WANG
;
Guo FENG
;
Dong YU-LIN
;
Xiong KANG-HUI
;
Li JIN-LIAN
Author Information
1. Fourth Military Medical University
- Keywords:
fluorogold;
motor trigeminal nucleus;
immunohistochemistry;
tyrosine kinase receptor;
axotomy;
rat
- From:
Neuroscience Bulletin
2005;21(3):193-197
- CountryChina
- Language:Chinese
-
Abstract:
Objective With double-labeling technique, the present study aims to observe the effects of nerve transection on the trigeminal motoneurons innervating masseter with regard to the expression of high-affinity neurotrophin receptors, viz. tropomyosin-related kinase (Trk) receptors: TrkA, TrkB and TrkC. Methods 7 and 14 d following masseteric nerve transection in the rat, brain sections were processed immunohistochemically for the detection of the three Trk isoforms on the motor trigeminal nucleus ( Mo5 ) neurons, which were retrogradely identified with FluoroGold (FG). Results The results showed ( 1 ) no significant change in the percentage of TrkA-immunoreactive (IR) neurons to the total FG-la-beled neurons ( P ＞ 0.05 ), (2) up-regulation of TrkB at both 7 and 14 d after axotomy ( P ＜ 0.05 ) and ( 3 ) down-regu-lation of TrkC 14 d following nerve transection (P ＜ 0.05). Conclusion The expression of the individual Trk receptors on the Mo5 neurons were differentially regulated post masseteric nerve transection.
