Increase of firing rate with changes in firing pattern of neurons of the pedunculopontine nucleus in 6-hydrodopamine lesioned rats
- VernacularTitle:6-羟多巴胺毁损的帕金森病模型大鼠脚桥核神经元放电频率和放电形式的变化
- Author:
Wang YONG
1
;
Zhang QIAO-JUN
;
Liu JIAN
;
FENG JIE
;
Chu YU-XIA
;
Gao RUI
;
Liu YA-PING
Author Information
1. 西安交通大学
- Keywords:
Parkinson's disease;
pedunculopontine nucleus;
6-hydroxydopamine;
firing rate;
firing pattern;
rat
- From:
Neuroscience Bulletin
2005;21(2):146-152
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the change in the firing rate and firing pattern of pedunculopontine nucleus (PPN)neurons in 6-hydrodopamine (6-OHDA) unilaterally lesiond rats. Methods Electrophysiological recordings of PPN neurons were done in normal rats and 6-OHDA lesiond rats with standard single unit glass microelectrode method in vivo. Results The firing rate of PPN neurons in normal rats and 6-OHDA lesiond rats were (9.0 ± 0.8 ) Hz [ (0.5-25.2) Hz, n = 56 ] and ( 16. 1 ± 1.6) Hz [ (1.2-49.7) Hz, n= 57), respectively. The firing rate of 6-OHDA lesioned rats was significantly increased when compared to control rats (P ＜ 0. 001 ). Concerning the firing pattern, 68% (38/56) of the neurons recorded discharged regularly, 27% (15/56) exhibited an irregular pattern and 5% (3/56) discharged in bursts in normal rats. In 6-OHDA lesioned rats, 39% (22/57) discharged regularly, 47% (27/57) exhibited an irregular pattern and 14% (8/57) in bursts. The number of PPN neurons in 6-OHDA lesioned rats fired irregularly was significantly higher than in control rats ( P ＜ 0.05). Conclusion The firing rate and the percentage of the irregularly firing neuron in PPN of 6-OHDA lesioned rats increased significantly, which may be contributed to the pathophysiological changes of Parkinson's disease.
