Tubular aggregates in systemic lupus erythematosus:A case report and review of literature
10.3969/j.issn.1002-0152.2024.10.013
- VernacularTitle:系统性红斑狼疮伴微管聚集1例报告并文献复习
- Author:
Xiaomei LAI
1
;
Xiaowei ZHU
;
Xiaojie ZHANG
;
Xinghua LUAN
;
Wenzheng WANG
Author Information
1. 江西省瑞金市人民医院神经内科(瑞金 342400)
- Keywords:
Systemic lupus erythematosus;
Muscle weakness;
Muscle biopsy;
Tubular aggregates;
Tubular aggre-gate myopathy;
Tubular aggregate myopathy of drugs;
Mixed connective tissue disease
- From:
Chinese Journal of Nervous and Mental Diseases
2024;50(10):636-640
- CountryChina
- Language:Chinese
-
Abstract:
Tubular aggregates(TA)are ultrastructural abnormalities in muscle biopsies,which can be detected in muscle biopsy specimens from patients with a variety of hereditary and acquired disorders.A 34-year-old male patient diagnosed with systemic lupus erythematosus(SLE)presented with intermittent muscle weakness localized to the proximal extremities of both lower limbs during prolonged oral administration of methylprednisolone,hydroxychloroquine and tacrolimus.Laboratory findings indicated normal creatine kinase levels,and anti-U1-RNP/Sm antibodies were elevated up to 49.45 RU/mL.Electromyography revealed myogenic lesions in the left iliopsoas muscle and muscle pathology demonstrated TA within the muscle fibers.Genetic testing excluded the possibility of hereditary disorders with tubular aggregas.Combined with literature review,the etiology and clinical characteristics of TA were discussed to increase the understanding of the diagnosis of diseases with TA.This case report demonstrates that SLE patients can have fluctuating muscle weakness and TA in muscle pathology.The symptoms of SLE can be partially relieved by adjusting SLE medications.
