Research progress on the pathological mechanism of bipolar disorder with mixed features
10.3969/j.issn.1002-0152.2024.10.009
- VernacularTitle:双相障碍伴混合特征的病理机制研究进展
- Author:
Ni ZHOU
1
,
2
;
Zuowei WANG
;
Yiming CHEN
;
Wu HONG
Author Information
1. 上海交通大学医学院附属精神卫生中心(上海 200030)
2. 上海市虹口区精神卫生中心
- Keywords:
Bipolar disorder;
Mixed features;
Pathological mechanism;
Neurotransmitter imbalance;
Neuroendo-crine;
Circadian rhythm disorder;
Neuroimaging
- From:
Chinese Journal of Nervous and Mental Diseases
2024;50(10):614-618
- CountryChina
- Language:Chinese
-
Abstract:
Bipolar disorder with mixed features is currently a prevalent clinical phenomenon,with patients exhibiting a heightened risk of suicidal behaviour,suboptimal therapeutic outcomes,poor prognostic indicators and frequently accompanied by significant impairment in psychosocial functioning.The current body of research on the pathological mechanisms of bipolar disorder with mixed features has proposed several mechanisms including neurotransmitter imbalance leading to abnormal emotion regulation,hypothalamic-pituitary-adrenal(HPA)dysfunction triggering an excessive stress response,circadian rhythm disorder affecting the sleep pattern,abnormal functional connectivity of the cerebral cortex and limbic system,independent and multidirectional changes in four dimensions,such as behaviour,cognition,mood,and sleep.Further studies are required to integrate the results of neurobiology,imaging,genetics and other multidisciplinary fields in order to provide more precise targets for the diagnosis and treatment of bipolar disorder with mixed features.
