Study on microstructural changes in white matter fibers of patients with post stroke depression based on automated fiber quantification
10.3969/j.issn.1002-0152.2024.10.003
- VernacularTitle:基于自动纤维定量技术研究卒中后抑郁的纤维束改变
- Author:
Qiuhong LU
1
,
2
;
Yanlan HUANG
;
Jie LIU
;
Miao WANG
;
Zhijian LIANG
;
Shunzu LU
Author Information
1. 广西医科大学第一附属医院神经内科(南宁 530021)
2. 广西医科大学第一附属医院心理卫生科
- Keywords:
Post stroke depression;
Ischemic stroke;
Structural damage;
Automated fiber quantification;
Diffu-sion tensor imaging
- From:
Chinese Journal of Nervous and Mental Diseases
2024;50(10):586-591
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the microstructural changes in white matter(WM)fibers of patients with post-stroke depression(PSD)by using automated fiber quantification(AFQ)and the relationship between changes in fibers and the Hamilton depression scale(HAMD).Methods The HAMD and MRI data were collected from stroke patients with a single anterior circulation infarction at 1-month follow-up.AFQ was used to extract the main fibers and calculate the fractional anisotropy(FA)of each node in each fiber.The difference of node FA in each fiber between groups and correlations between altered node FA and HAMD were then evaluated.Results Data were collected from 8 patients with PSD and 18 patients without PSD(non-PSD).Compared with that in non-PSD,the node FA in the callosum,left inferior longitudinal fasciculus,and uncinate fasciculus were significantly decreased in patients with PSD(P<0.05).The altered node FA values in the corpus callosum forceps minor(r=-0.418,P=0.047)and left uncinate fasciculus(r=-0.467,P=0.029)were negatively related to HAMD in patients with PSD.Conclusions AFQ can precisely measure the segmental microstructural damage of nerve fiber bundles in patients with PSD,of which segmental microstructural damage of the corpus callosum forceps and hook tracts is associated with the severity of depression.
