Cerebellar symptoms and imaging features in neurodegenerative diseases
10.3969/j.issn.1002-0152.2024.09.010
- VernacularTitle:神经退行性疾病的小脑症状与影像学特征
- Author:
Xinhui QIU
1
;
Tao QIU
;
Meichen LIU
;
Tianbai LI
;
Weidong LE
Author Information
1. 大连医科大学附属第一医院神经疾病研究所(大连 116000)
- Keywords:
Cerebellum;
Neurodegenerative diseases;
Parkinson disease;
Alzheimer disease;
Neuroimaging;
Motor dysfunction;
Cognitive impairment;
Clinical assessment methods
- From:
Chinese Journal of Nervous and Mental Diseases
2024;50(9):570-576
- CountryChina
- Language:Chinese
-
Abstract:
Pathological,electrophysiological,and neuroimaging changes in the cerebellum can occur in neurodegenerative diseases such as Alzheimer disease,Parkinson disease,and amyotrophic lateral sclerosis.The activation and neurodegeneration of neurons in specific cerebellar regions may contribute to the clinical symptoms and pathological processes of these neurodegenerative diseases.This article reviews the clinical assessment methods and neuroimaging studies related to cerebellar symptoms in neurodegenerative diseases.The findings suggest that structural and functional abnormalities of the cerebellum are associated with symptoms such as motor,cognitive,and emotional dysfunction in these diseases.Developing a multidimensional,systematic clinical and imaging evaluation approach centered on the cerebellum will help deepen our understanding of the cerebellum's role in the pathogenesis of neurodegenerative diseases.It will also provide new directions for the early identification of symptoms,differential diagnosis,and the formulation of precise treatment plans.
