Clinical characteristics of late-life depression patients with venous thromboembolism in the elderly ward
10.3969/j.issn.1002-0152.2024.09.005
- VernacularTitle:老年抑郁症住院患者合并静脉血栓栓塞临床特征
- Author:
Wenfeng ZHEN
1
,
2
;
Jing YANG
;
Dandi ZHU
;
Xianglin MA
;
Qing'e ZHANG
Author Information
1. 首都医科大学附属北京安定医院,国家精神疾病医学中心,精神疾病诊断与治疗北京市重点实验室(北京 100088)
2. 首都医科大学人脑保护高精尖创新中心(北京 100069)
- Keywords:
Late-life depression;
Inpatient;
Venous thromboembolism;
Clinical characteristics;
Bedridden;
D-dimer
- From:
Chinese Journal of Nervous and Mental Diseases
2024;50(9):546-551
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical characteristics and related to risk factors of late-life depression patients with venous thromboembolism in the elderly ward.Methods A retrospective analysis was conducted on 143 hospitalized depression patients(aged≥60 years)including 65 depression patients with VTE(VTE group)and 78 depression patients without VTE(control group)in the elderly ward of Beijing Anding Hospital from January 2023 to September 2023.The clinic and laboratory data was collected such as general demographic information,relevant clinical data,VTE history,personal history,thyroid function,hormone levels,blood lipid levels and D-dimer to analyze and compare the clinical characteristics of two group patients,and Logistic regression was used to analyze the related risk factors of VTE in patients with depression.Results Compared with control group,patients in the VTE group were older[(70.94±5.88)years vs.(68.04±4.92)years,P<0.05],had a higher total HAMD score(26.35±9.28 vs.23.19±5.94,P<0.05),a higher proportion of a history of VTE[13 cases(20.0%)vs.6 cases(7.7%),P<0.05],a higher proportion of bedridden for more than 72 hours[42 cases(64.6%)vs.31 cases(39.7%),P<0.05],lower HDL-C levels[(1.27±0.27)mmol/L vs.(1.39±0.28)mmol/L,P<0.05],and higher levels of D-dimer[1.91(0.82,3.51)mg/L FEU vs.0.48(0.25,0.80)mg/L FEU,P<0.05].Logistic regression analysis showed that total HAMD scores(OR=1.077,P=0.018),history of VTE(OR=4.339,P=0.023),bedridden for more than 72 hours(OR=2.449,P=0.044),and D-dimer level(OR=2.404,P<0.001)were risk factors for hospitalized late-life depression patients with VTE in the elderly ward.Conclusions Depression patients with VTE in the elderly ward have several clinical characteristics including older age,more severe depressive symptoms,lower HDL-C levels,higher D-dimer levels,and higher proportion of a history of VTE and bedridden for more than 72 hours.Depressive symptoms,a history of VTE,bedridden for more than 72 hours,and D-dimer levels may be risk factors for late-life depression patients with VTE in the elderly ward.
