Molecular basis underlying gray matter volume changes in patients with AIWG:a transcriptome-neuroimaging study
10.3969/j.issn.1002-0152.2024.09.004
- VernacularTitle:抗精神病药物所致体质量增加患者灰质体积变化的神经影像-转录分析
- Author:
Suzhen ZHANG
1
;
Xinping KUAI
;
Tianhao GAO
;
Xuan LI
;
Kaiming ZHUO
;
Qiong XIANG
;
Deng-Tang LIU
Author Information
1. 上海交通大学医学院附属精神卫生中心(上海 200030)
- Keywords:
Schizophrenia;
Antipsychotic;
Weight gain;
Gray matter volume;
Thalamus;
AHBA;
Gene expres-sion
- From:
Chinese Journal of Nervous and Mental Diseases
2024;50(9):540-545
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the gray matter volume(GMV)changes and molecular basis underlying antipsychotic-induced weight gain(AIWG).Methods One hundred twenty-nine first-episode schizophrenia patients from October 2019 to December 2021 were enrolled in this study.Patients with≥7%weight gain(weight gain,WG)and patients with<3%weight changes(weight stable,WS)were studied.All patients underwent T1-weighted MRI scanning at baseline and after 8 week treatment.Transcriptome-neuroimaging correlations were used to investigate brain gene profiles from the Allen Human Brain Atlas and GMV changes induced by AIWG.Results Thirty-three patients with WG and 27 with WS completed the GMV measures.Compared with baseline,the WG group showed reduced GMV in right hippocampus,left basal ganglia,and right inferior parietal lobule,etc.and increased GMV in bilateral thalamus(P<0.05).The WS group showed reduced GMV in bilateral orbital gyrus,bilateral inferior frontal gyrus and bilateral hippocampus(P<0.05).These GMV changes in WG group were spatially correlated with expression levels of 354 genes,which were exclusively enriched in Cushing syndrome,neuroinflammation and glutamatergic signaling,and Pnoc+.Conclusion The study has demonstrated increased GMV in thalamus in schizophrenia patients with AIWG which may be associated with Cushing syndrome and Pnoc+.These findings may provide important insights into the molecular mechanisms of AIWG.
