Research progress on brain structure and function in patients with major depressive disorder after modified electroconvulsive therapy
10.3969/j.issn.1002-0152.2024.08.009
- VernacularTitle:无抽搐电休克治疗对重性抑郁障碍脑结构功能影响研究进展
- Author:
Yiyi YANG
1
;
Yawen HONG
;
Yongguang HE
;
Jijun WANG
;
Tianhong ZHANG
Author Information
1. 上海交通大学医学院附属精神卫生中心脑电影像研究室(上海 200030)
- Keywords:
Electroconvulsive therapy;
Major depressive disorder;
Magnetic resonance imaging;
Gray matter;
White matter;
Nerve net;
Neuronal plasticity
- From:
Chinese Journal of Nervous and Mental Diseases
2024;50(8):503-507
- CountryChina
- Language:Chinese
-
Abstract:
Modified electroconvulsive therapy(MECT)has a good therapeutic effect on major depressive disorder(MDD),but its mechanism of action is still unclear.In recent years,accumulated studies have confirmed the effects of MECT on brain structure and function using neuroimaging techniques and large datasets obtained through global collaborations and the conclusions are becoming increasingly consistent.For example,there is an increase in gray matter volume in specific brain regions such as the hippocampus and amygdala,an increase in white matter microstructural integrity and normalization of brain functional connections associated with MDD,such as the hippocampus-amygdala-subgenual anterior cingulate cortex-prefrontal cortex network,hippocampus-thalamus-temporal cortex-parietal cortex network,etc.However,the relationship between these changes and the mechanism of MECT action still needs further investigation.This review provides an overview of the research progress on the structural and functional changes of the brain by MECT to provide methodological support and theoretical basis for its better application in clinical diagnosis and treatment.
