Research progress on the relationship between attention deficit and hyperactive disorder and inflammation
10.3969/j.issn.1002-0152.2024.08.008
- VernacularTitle:注意缺陷多动障碍与炎症关系的研究进展
- Author:
Yongchang ZHANG
1
;
Caiyan LIU
;
Xiangzhen FU
;
Lingling SHI
Author Information
1. 暨南大学附属第一医院精神医学科(广州 510630)
- Keywords:
Attention deficit and hyperactive disorder;
Inflammation;
Cytokine;
Neurotransmitters;
Immunity;
Blood-brain barrier;
Biomarker
- From:
Chinese Journal of Nervous and Mental Diseases
2024;50(8):498-503
- CountryChina
- Language:Chinese
-
Abstract:
The pathogenesis of attention deficit and hyperactive disorder(ADHD)remains unclear.Evidence from epidemiological,biomarker,and genetic studies indicates that inflammation may play a crucial role in ADHD development.Inflammation can influence the onset and progression of ADHD through various mechanisms,such as activation of the hypothalamic-pituitary-adrenal(HPA)axis,alterations in neurotransmitter metabolism,maternal immune activation,disruption of the blood-brain barrier integrity,and impacts on neurodevelopment.A deeper understanding of the relationship between inflammation and ADHD could provide valuable insights into the pathophysiological mechanisms of ADHD and open new perspectives for clinical diagnosis and treatment.
