Comparison of abnormal cortical inhibition in schizophrenia and major depression disorder
10.3969/j.issn.1002-0152.2024.08.004
- VernacularTitle:精神分裂症和抑郁症大脑皮质抑制异常比较
- Author:
Guanfu WU
1
;
Tianyuan ZHU
;
Lihua XU
;
Zhenying QIAN
;
Jijun WANG
;
Yingying TANG
Author Information
1. 上海交通大学医学院附属精神卫生中心脑电影像室(上海 200030)
- Keywords:
Schizophrenia;
Depression;
Neural inhibition;
Cortical excitability;
Transcranial magnetic stimula-tion;
Short interval cortical inhibition;
Cortical silent period
- From:
Chinese Journal of Nervous and Mental Diseases
2024;50(8):476-482
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare cortical inhibition(CI)function between patients with schizophrenia and depression,and to explore the correlation between CI function and clinical symptoms.Methods A total of 35 first episode schizophrenia(FES)patients,41 depression patients(21 with first episode depression,20 with recurrent depression),and 35 healthy controls(HC)were recruited.The positive and negative syndrome scale(PANSS)was used to assess symptoms in FES patients,while the 17-item Hamilton depression scale(HAMD-17)and Hamilton anxiety scale(HAMA)were used to assess symptoms in depression patients.All participants'cortical inhibition and excitation measures were examined using single or paired pulses transcranial magnetic stimulation.Analysis of covariance/generalized linear model was employed to compare cortical inhibition and excitation measures among groups including age,gender,and medication status as covariates.The correlations between cortical inhibition and excitation measures and clinical symptoms were analyzed.Results The cortical silent period(CSP)in FES group was longer than that in control group and depression group[(92.08±35.43)ms vs.(70.27±22.12)ms vs.(70.81±29.29)ms,P<0.05].Depression group was further divided into first episode depression(FED)and recurrent depression(RD)subgroups.The short-interval cortical inhibition(SICI)was weaker in FED group than in the RD group and the control group(0.76±0.44 vs.0.43±0.32 vs.0.45±0.20,P<0.05).In FED group,CSP was negatively correlated with the general symptom score of PANSS(r=-0.544,P<0.001),and SICI was negatively correlated with the negative symptom score of PANSS(r=-0.501,P=0.005).In the FED group,SICI was positively correlated with HAMD-17 score(r=0.605,P=0.028).Conclusion Both FES patients and FED patients exhibit abnormal CI.There are distinct characteristics between FES and FED.FES patients exhibit prolonged CSP,while FED patients exhibit decreased SICI.The abnormal CI in FES and FED are correlated with their clinical symptoms.
