Association between cardiovascular autonomic function and voiding symptoms in Parkinson disease
10.3969/j.issn.1002-0152.2024.08.002
- VernacularTitle:帕金森病心血管系统自主神经功能与排尿症状相关性研究
- Author:
Ziqi GAO
1
,
2
,
3
;
Rui YANG
;
Wenlin HUANG
;
Mengfei CAI
;
Yuhu ZHANG
Author Information
1. 华南理工大学医学院(广州 510006)
2. 南方医科大学附属广东省人民医院(广东省医学科学院)神经科(广东省神经科学研究所)
3. 广州市神经退行性疾病诊治研究重点实验室
- Keywords:
Parkinson disease;
Cardiovascular autonomic dysfunction;
Lower urinary tract symptom;
Nocturnal hypertension;
Blood pressure variability;
Post void residual
- From:
Chinese Journal of Nervous and Mental Diseases
2024;50(8):463-469
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between cardiovascular autonomic function and voiding symptoms in Parkinson disease(PD)patients.Methods We reviewed PD patients from the Department of Neurology of Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences)between November 2020 and July 2023.Patients with PD were diagnosed by movement disorder specialists and received motor symptoms assessment based on Movement Disorders Society-Unified Parkinson's Disease Rating Scale part Ⅲ(MDS-UPDRS Ⅲ).We included those patients who underwent 24-hour ambulatory blood pressure monitoring(ABPM),ultrasound measured post void residual(PVR)and uroflowmetry.Subjects were divided into two groups:PD patients with nocturnal hypertension(PD-NH)group and PD patients without nocturnal hypertension(PD-nNH)group,according to the average nocturnal blood pressure.General clinical features,clinical assessments and urinary evaluations were compared between the two groups.We calculated average real variability(ARV)and examined its correlation factors using generalized linear models.Results Among the total of 87 PD patients,46(52.87% )were found to have nocturnal hypertension(NH).The PD-NH group exhibited more PVR[1.00(0.00,21.25)mL]compared to the PD-nNH group[0.00(0.00,5.50)mL](P<0.05).Additionally,generalized linear model analysis which scale response is Gamma with log link showed in PD patients,ARV of 24-hour diastolic blood pressure was correlated with PVR(OR=1.003,95% CI:1.001-1.005,P=0.008)and sex(male,OR=1.234,95% CI:1.050-1.451,P=0.011).Conclusion Our study demonstrates the association between cardiovascular autonomic function and voiding symptoms in PD.
