A case report of Parkinson disease complicated with myasthenia gravis
10.3969/j.issn.1002-0152.2024.07.007
- VernacularTitle:帕金森病合并重症肌无力1例
- Author:
Li YANG
1
;
Fangming LI
;
Xiaowu CHEN
;
Hongya ZHANG
Author Information
1. 深圳大学总医院神经内科(深圳 518055)
- Keywords:
Parkinson disease;
Myasthenia gravis;
Comorbidity;
Treatment strategies;
Pyridostigmine;
Levodopa-benserazide
- From:
Chinese Journal of Nervous and Mental Diseases
2024;50(7):437-439
- CountryChina
- Language:Chinese
-
Abstract:
This case report described an 80-year-old male patient with Parkinson disease(PD)complicated with myasthenia gravis(MG).Six years ago,the patient was diagnosed with PD based on the motor symptoms including bradykinesia and static tremor and treated with levodopa-benserazide and piribedil sustained-release tablets.He was admitted to the hospital due to left eyelid ptosis one month ago.The result of Neostigmine test was positive and anti-acetylcholine receptor(AChR)antibodies of serum was positive,which met the diagnostic criteria for myasthenia gravis(MG).The symptom of MG improved significantly after treatment with glucocorticoid and pyridostigmine but the PD symptoms worsened.The symptoms of PD were improved after withdrawal of pyridostigmine and use of the levodopa-benserazide and his condition maintained stable at 3 years of follow-up.The PD complicated with MG was fairly rare.We also reviewed the literature on the possible comorbidity mechanism and treatment strategies to improve the comprehensive understanding and ability of diagnosis and treatment of clinicians.
