Study of the correlation between red blood cell distribution width,systemic immune-inflammation index with major depressive disorder
10.3969/j.issn.1002-0152.2024.07.003
- VernacularTitle:红细胞分布宽度、系统免疫炎症指数与重性抑郁障碍的相关性研究
- Author:
Man JIN
1
,
2
;
Hao LIANG
;
Shipan ZHANG
;
Xueru ZHANG
;
Peng JING
;
Yue YANG
;
Chunyang WANG
;
Peiyuan LYU
Author Information
1. 河北医科大学(石家庄 050051)
2. 河北省人民医院神经内科 河北省脑网络与认知功能重点实验室
- Keywords:
Red blood cell distribution width;
Major depressive disorder;
Systemic immune-inflammation index;
Red blood cell distribution width to platelet ratio;
Inflammatory response;
Correlation studies;
Risk factors
- From:
Chinese Journal of Nervous and Mental Diseases
2024;50(7):409-414
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between red blood cell distribution width(RDW),systemic immune-inflammation index(SII)and major depressive disorder(MDD).Methods The clinical data of 176 MDD patients hospitalized in the clinical psychology department of our hospital from 2020 to 2022 and 209 non-MDD comparators who were routinely examined in Hebei General Hospital were retrospectively analyzed.Blood analysis was conducted to obtain values of RDW,SII,and red blood cell distribution width/platelet ratio(RPR).The data was used to plot the receiver operator characteristic(ROC)curve to determine the optimal threshold and the area under the curve(AUC)for RDW to discriminate between patients and controls.Result Patients in the MDD group had significantly higher RDW[median and quartiles:13.20(12.70,13.98)vs.12.80(12.40,13.35)],and SII levels[median and quartiles 510.87(350.95,878.12)vs.405.33(313.74,539.92)]compared with those in non-MDD group(P<0.05).There was no significant difference in RPR between the two groups(P>0.05).Multifactorial logistic regression analysis showed that RDW was positively correlated with MDD after adjusting for confounders(OR=3.086,95% CI:1.926-4.944).ROC curve showed that the optimal threshold for RDW to differentiate the risk of developing MDD was 12.85,with an AUC of 0.647(95% CI:0.592-0.702;P<0.001).Conclusion Present study shows that high RDW is a risk factor for the occurrence of MDD and an important parameter for the risk of developing depression.
