An intervention study of right unilateral modified electroconvulsive therapy for major depressive disorder
10.3969/j.issn.1002-0152.2024.06.004
- VernacularTitle:右单侧刺激电休克治疗对重性抑郁障碍的干预研究
- Author:
Pei TAN
1
,
2
;
Yixiao FU
;
Qinghua LUO
;
Lian DU
;
Tian QIU
;
Haitang QIU
Author Information
1. 重庆医科大学附属第一医院精神科(重庆 400016)
2. 重庆市精神卫生中心
- Keywords:
Major depressive disorder;
Modified electroconvulsive therapy;
Right unilateral modified electrocon-vulsive therapy;
Cognitive function;
Recovery of orientation;
Clinical efficacy;
Safety
- From:
Chinese Journal of Nervous and Mental Diseases
2024;50(6):337-342
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect and safety of right unilateral modified electroconvulsive therapy(RUL-MECT)for major depressive disorder patients(MDD).Methods A randomized controlled trial was conducted on 70 patients with MDD who were randomly divided into a study group and a control group.The study group underwent age-based RUL-MECT,while the control group underwent bitemporal MECT.The participants were evaluated using the 17-item Hamilton depression scale(HAMD-17),MATRICS consensus cognitive battery(MCCB)and orientation recovery tests(ORT).Any adverse reactions that occurred during each intervention process were recorded.Results Before treatment,there were no significant differences in the HAMD-17(32.89±5.68 vs.33.54±4.78)between the two groups(P>0.05).The HAMD-17 score of the intervention group was 6.83±4.68,while the control group was 7.20±4.60 after 8 interventions,repeated measures analysis of variance showed the time effect(P<0.001)was significant.The intergroup effect and interaction effect was not significant(P>0.05).In terms of MCCB scores,there were significant main effect(P<0.001)in connectivity tests,symbol coding,language memory,spatial breadth,number sequence,maze test,visual memory,emotional management and the duration of continuous operation.The intergroup effects of language memory,number sequence,visual memory,speech fluency,and continuous operation were significant(P<0.05).The interaction effect of language memory and continuous operation were significant(P<0.05).After the intervention,the recovery of orientation time was significantly shorter in the study group than that in the control group[(508.57±104.48)s vs.(631.66±212.27)s](P<0.05).The incidence of adverse reactions between two groups(28.6% vs.40.0% )has no significance(P>0.05).Conclusions Compared with bitemporal MECT,RUL-MECT has comparable efficacy in treating depressant and better performance in improving cognitive function and recovery of orientation.
