The correlation between cognitive impairment and DNA methylation in the GRIN2B gene promoter region in bipolar depression patients with anxiety symptom
10.3969/j.issn.1002-0152.2024.05.004
- VernacularTitle:伴有焦虑症状双相抑郁患者认知功能损害与GRIN2B基因启动子区DNA甲基化相关性研究
- Author:
Hao YU
1
,
2
;
Chengji WANG
;
Yao WU
;
Shaohong ZOU
Author Information
1. 新疆医科大学(乌鲁木齐 830000)
2. 新疆维吾尔自治区人民医院临床心理科
- Keywords:
DNA methylation;
Bipolar disorder;
Depressive episode;
Cognition;
Anxiety symptoms;
N-methyl-D-aspartate receptor 2B subunit
- From:
Chinese Journal of Nervous and Mental Diseases
2024;50(5):274-280
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between cognitive function and methylation levels of various CpG sites in the promoter region of the glutamate ionotropic receptor NMDA type subunit 2B(GRIN2B)gene in patients with bipolar depression accompanied by anxiety symptoms.Methods According to the 14-item Hamilton anxiety rating scale(HAMA)score,31 bipolar depression patients were divided into a group of 15 with anxiety symptoms and a group of 16 without anxiety symptoms.Sixteen healthy individuals were selected as controls during the same period.The Montreal cognitive assessment(MoCA),digital span test(DST),trail making test A(TMT-A),and Stroop color and word test(SCWT)were used to measure cognitive areas such as global cognitive function,attention and executive control,information processing speed,executive function in three groups.The DNA methylation levels of the CpG site in the GRIN2B gene promoter region in the peripheral blood of all participants were measured using Massarray spectrometry.Results The CpG sites showing differences in DNA methylation levels among the three groups were CpG3,CpG5,CpG7,CpG10,and CpG12(P<0.05),and the level of CpG12 methylation was lower in the group with anxiety than in the group without anxiety(36.23%±16.41%vs.50.20%±19.79%,P<0.05).Partial correlation analysis showed that,in the group with anxiety,poor naming ability was correlated with the lower methylation level of GRIN2B gene's CpG4(r=0.670,P=0.034),poor executive function was correlated with the lower CpG6 methylation level(r=0.926,P<0.001),poor attention was correlated with the higher CpG8 methylation level(r=-0.810,P=0.025),poor verbal memory was correlated with the higher CpG9 methylation level(r=-0.810,P<0.001),and poor abstract ability was correlated with the higher CpG10 methylation level(r=-0.756,P=0.011).Conclusion The DNA methylation level in the promoter region of the GRIN2B gene may be associated with cognitive impairment and anxiety symptoms in patients with bipolar depression.
