Effect of injection volume on clinical efficacy after minimally invasive puncture and drainage in the treatment of moderate basal ganglia cerebral hemorrhage underlying controlling the dosage of drugs in the elderly
10.3969/j.issn.1002-0152.2024.05.003
- VernacularTitle:注射体积对老年患者中等量基底节区脑出血微创穿刺术后临床疗效的影响
- Author:
Liang WANG
1
;
Wei DONG
;
Lian ZHENG
;
Jinmiao ZHANG
;
Ding YUAN
;
Guo CHENG
Author Information
1. 重庆市第五人民医院神经外科(重庆 400036)
- Keywords:
Minimally invasive puncture and drainage;
Basal ganglia;
Cerebral hemorrhage;
Volume;
Elderly;
Hematoma clearance rate;
Intracranial pressure
- From:
Chinese Journal of Nervous and Mental Diseases
2024;50(5):268-273
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of injection volume on clinical efficacy after minimally invasive puncture and drainage in the treatment of moderate basal ganglia cerebral hemorrhage underlying controlling the dosage of drugs in the elderly.Methods After successfully inserting the puncture needle into the center point in the largest layer long axis,the liquid hematoma was aspirated,and 40,000 units urokinase was injected into the hematoma cavity twice a day(2 mL in the small volume Group(SG),and 4 mL in the large volume group(LG),respectively).The needle were then adjusted and removed according to the hematoma clearance.The clearance rate of hematoma,intracranial pressure,edema volume,mortality,incidence of complications,neurological deficit score(NDS)and activities of daily living(ADL)were compared and analyzed.Results There were no significant differences in the first hematoma clearance rate,postoperative ICP and mortality between the two groups(P>0.05).Comparing to the SG,there was a relative higher postoperative hematoma clearance rate and lower volume of perihematoma edema in the LG(P<0.05).Meanwhile,the needle retention time,urokinase usage and cumulative complications at 28 days after operation were lower than in the SG(P<0.05).For two parameters representing long-term outcome,the NDS and ADL scores were much better in LG than in SG(P<0.05).Conclusion Large volume injection can effectively drain the hematoma,shorten the needle retention time,reduce the usage of urokinase,decrease the incidence of postoperative complications and improve the prognosis of patients,thereby providing effective and safe method in treating moderate basal ganglia cerebral hemorrhage in the elderly.
