The clinical value of visual evoked potential in assessing visual pathway of visual hallucinations in Parkinson disease
10.3969/j.issn.1002-0152.2024.05.001
- VernacularTitle:视觉诱发电位评估帕金森病视幻觉视觉传导通路临床价值
- Author:
Xiang LI
1
;
Qilin ZHANG
;
Fei CHEN
;
Hao GUI
;
Yongping DAI
Author Information
1. 苏州大学附属第二医院神经电生理室(苏州 215004)
- Keywords:
Parkinson disease;
Visual hallucination;
Visual evoked potentials;
Visual pathway;
Bottom-up
- From:
Chinese Journal of Nervous and Mental Diseases
2024;50(5):257-262
- CountryChina
- Language:Chinese
-
Abstract:
Objective This research was to evaluate the integrity of visual pathways in patients with Parkinson disease(PD)by visual evoked potential(VEP),especially those with visual hallucinations.Methods A total of 76 PD patients were enrolled in this study.According to the presence or absence of visual hallucinations,they were divided into two groups:24 patients with visual hallucinations and 52 patients without visual hallucinations.At the same time,22 sex-and age-matched healthy controls were selected.All subjects underwent VEP test,and Unified Parkinson's Disease Rating Scale(UPDRS),Hoehn&Yahr stage(H-Y stage)and Mini-mental State Examination(MMSE)were performed for PD patients.Results The latencies of N75,P100 and N135(88.26±10.47)ms,(118.48±8.53)ms,(144.71±9.48)ms were significantly longer in PD patients with visual hallucinations than in those without visual hallucinations[(79.00±6.96)ms,(108.60±7.01)ms,(135.95±8.21)ms](P<0.001).However,the amplitudes of N75-P100 and N135-P100[4.35(2.73,7.30)μV]、[6.40(4.15,9.90)μV]were significantly lower in PD patients with visual hallucinations than in those without visual hallucinations[7.10(5.28,9.98)μV]、[9.05(6.30,12.60)μV](P<0.001,P=0.037).Correlation analysis showed that P100 latency was positively correlated with H-Y stage,UPDRS-I,UPDRS-II,and UPDRS-III scores(r=0.537,P=0.007),(r=0.635,P=0.001),(r=0.594,P=0.004)and(r=0.558,P=0.005)in PD visual hallucinations group.Conclusion The integrity of the visual pathway is impaired in PD patients with visual hallucinations.As the progression of the disease,the impairment of visual pathway may be further deteriorated,which may extend beyond the upper pathways of visual pathway to the brain.
