Differences in non-enzymatic antioxidant levels between later-life depression and younger depression
10.3969/j.issn.1002-0152.2024.04.005
- VernacularTitle:老年与中青年抑郁障碍患者非酶抗氧化物水平差异
- Author:
Ning FAN
1
;
Qi ZHANG
;
Luyuan BAI
;
Wenxuan ZHAO
;
Yajun YUN
;
Jiangling YAN
;
Xiaole HAN
;
Fude YANG
Author Information
1. 北京回龙观医院老年科(北京 100096)
- Keywords:
Depression;
Elderly people;
Non-enzymatic antioxidants;
Uric acid;
Albumin;
Bilirubin
- From:
Chinese Journal of Nervous and Mental Diseases
2024;50(4):227-231
- CountryChina
- Language:Chinese
-
Abstract:
Objective This study aimed to investigate the levels of non-enzymatic antioxidants among patients with depression at different age stages.Methods One hundred thirty five patients with depression(including 63 elderly patients aged 60 years and older,and 72 young and middle-aged patients under 60 years old)and 98 healthy controls(including 46 elderly controls aged 60 years and older,and 52 young and middle-aged controls aged under 60 years old)were enrolled.Serum levels of non-enzymatic antioxidants(uric acid,total bilirubin,albumin)were assessed.Results Multiple analysis of variance showed the main effects of depression factors on uric acid and total bilirubin were significant(P<0.05).Uric acid[(314.30±85.18)μmol/L vs.(339.68±85.27)μmol/L],total bilirubin[(12.81±6.16)μmol/L vs.(15.09±5.97)μmol/L]levels were lower in patients with depression than in controls(P<0.05).There was an interactive effect between age and depression factors on the levels of albumin(P<0.001),and the levels of albumin[(41.05±3.97)g/L vs.(46.01±4.49)g/L]were lower in group of the elderly patients with depression than those in group of the young and middle-aged patients with depression(P<0.01).Conclusion Patients with depression have abnormalities in levels of non-enzymatic antioxidants which are more severe in elderly patients.
