Investigating the distant thalamic and substantia nigra damage in patients with cerebral infarction based on voxel morphology analysis
10.3969/j.issn.1002-0152.2024.04.003
- VernacularTitle:基于体素形态学分析探讨脑梗死远隔丘脑和黑质损害研究
- Author:
Danxia CHEN
1
,
2
;
Bingdong XU
;
Fengling PI
;
Yusheng ZHANG
Author Information
1. 梅州市人民医院神经内科
2. 暨南大学附属第一医院神经内科(广州 510630)
- Keywords:
Voxel-based morphometry;
Middle cerebral artery;
Cerebral infarction;
Thalamus;
Substantia nigra;
Secondary damage;
Magnetic resonance imaging
- From:
Chinese Journal of Nervous and Mental Diseases
2024;50(4):215-220
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical values of voxel-based morphometry(VBM)analysis in magnetic resonance imaging(MRI)for detecting secondary damage to the distant thalamus and substantia nigra in patients with cerebral infarction.Methods A total of nineteen patients with first-time unilateral middle cerebral artery(MCA)ischemic stroke were prospectively recruited.Three-dimensional whole-brain MRI scans were performed at 1 week,1 month,and 3 months after onset.VBM analysis was used to analyze changes in the thalamus and substantia nigra volumes.Results VBM analysis revealed that compared to ipsilateral thalamic volume at 1 week after onset,ipsilateral thalamic volume was significantly reduced at 1 month or 3 months after onset(reduced by 637 mm3 and 1488 mm3,respectively;P<0.01),with the atrophy primarily located in the dorsomedial nucleus of the thalamus.Similarly,compared to ipsilateral substantia nigra volume at 1 week after onset,the ipsilateral substantia nigra volume was significantly reduced at 1 month or 3 months after onset(reduced by 64 mm3 and 76 mm3,respectively;P<0.05).Conclusions VBM technology can be used to evaluate the ipsilateral thalamic and substantia nigra volume reduction in patients with cerebral infarction in the MCA supply area at 1-3 months after stroke,and to detect secondary damage.
