Rapid progressive dementia and involuntary movement caused by vitamin B12 deficiency:a case report
10.3969/j.issn.1002-0152.2024.03.009
- VernacularTitle:维生素B12缺乏引起的快速进展性痴呆、不自主运动1例
- Author:
Lanlan LIU
1
;
Xin JIANG
;
Xuewei XING
;
Yanqing TIE
;
Guosong QI
;
Jingjing WANG
;
Xiaoxiao FENG
;
Peiyuan LYU
Author Information
1. 河北北方学院研究生院(张家口 075000)
- Keywords:
Vitamin B12 deficiency;
Rapidly progressive dementia;
Involuntary movement;
Pernicious anemia;
Anti-intrinsic factor antibody;
Hyperhomocysteinemia;
Peripheral nerve crush lesion
- From:
Chinese Journal of Nervous and Mental Diseases
2024;50(3):165-167
- CountryChina
- Language:Chinese
-
Abstract:
A 41-year-old male was presented with rapidly progression memory impairment for 2 months and episodic limb shaking for 2 weeks as the main manifestations.Physical examination showed verbal disadvantage with decreased memory,attention,comprehension,and orientation.Serum vitamin B12 levels decreased,serum anti gastric parietal cell antibodies and anti-intrinsic factor antibodies were positive.Blood analysis showed macrocytic anemia,neuropsychological scale showed functional impairment in multiple cognitive domains,electrophysiological examination showed peripheral nerve damage,cerebrospinal fluid and imaging examination showed no abnormalities.The patient was diagnosed as having vitamin B12 deficiency dementia,vitamin B12 deficiency related involuntary movement and pernicious anemia.Supplementing with B vitamins and folic acid significantly improved cognitive impairment and eliminated symptoms of limb shaking.The purpose of this case report is to enhance the understanding of clinical doctors about dementia and involunting movement caused by vitamin B12 deficiency,in order to diagnose and treat it early.
