Advances in lipopolysaccharide structural variations and immune escape in Yersinia pestis
10.3969/j.issn.1002-2694.2024.00.134
- VernacularTitle:鼠疫耶尔森菌LPS结构变异机制及其免疫逃逸功能研究进展
- Author:
Wen-Jing FENG
1
;
Yuan ZHANG
;
Zong-Min DU
Author Information
1. 牡丹江医学院公共卫生学院,牡丹江 157011
- Keywords:
Yersinia pestis;
lipopolysaccharide(LPS);
immune escape
- From:
Chinese Journal of Zoonoses
2024;40(9):860-866
- CountryChina
- Language:Chinese
-
Abstract:
Plague,caused by Yersinia pestis,is a zoonotic disease that infects both humans and animals.Y.pestis not only encodes various virulence factors that can disrupt host immune signaling but also can modify its lipopolysaccharide(LPS)struc-ture,thereby evading host immune surveillance and potently suppressing the host's immune response,in an important molecu-lar mechanism underlying its high pathogenicity.The LPS of Y.pestis lacks an O antigen,and its lipid A structure possesses a unique temperature transition regulatory mechanism.At different temperatures,Y.pestis forms lipid A with different numbers of acyl side chains,which plays a pivotal role in the evasion of host innate immune recognition and clearance.Here,we present a comprehensive review of research progress in the biosynthetic regulation,structural variation,and immune escape mechanism of Y.pestis LPS,to provide a reference for the study of the molecular mechanisms of pathogens using LPS structural modifica-tions to elude host innate immune defenses.
