Molecular epidemiological analysis of group A rotavirus in diarrhea cases in children under 5 years of age in Guangdong Province,2021-2022
10.3969/j.issn.1002-2694.2024.00.130
- VernacularTitle:2021-2022年广东省5岁以下婴幼儿腹泻病例中A组轮状病毒分子流行病学分析
- Author:
Cai-Xia LI
1
;
Chang ZHANG
;
Wei ZHANG
;
Han-Ri ZENG
;
Huan-Ying ZHENG
;
Bo-Sheng LI
;
Bi-Xia KE
Author Information
1. 广东省疾病预防控制中心,广东省新发传染病应急检测技术研究与应用重点实验室,广州 511430
- Keywords:
rotavirus;
viral diarrhea;
genotype
- From:
Chinese Journal of Zoonoses
2024;40(9):834-840
- CountryChina
- Language:Chinese
-
Abstract:
This study investigated the epidemiological and genotypic characteristics of group A rotavirus(RVA)in children under 5 years of age with diarrhea at a viral diarrhea surveillance sentinel hospital in Guangdong Province from 2021 to 2022,to provide a basis for RVA prevention and control.A total of 1 858 fecal samples from children under 5 years of age with diarrhea in 2021-2022 were collected.Rotavirus antigen was detected with ELISA,and positive samples were further sequenced and categorized.Among the 1 858 samples,156 were RVA positive.The positivity rates in boys and girls were 8.76％and 7.87％,respectively.Significant differences were observed in the detection rates of RVA infection among age groups.The rate of RVA infection increased gradually from December to April of the following year.In 2021,the main endemic strains of RVA in the Guangdong region were of the G9P[8]subtype,and the rare G8P[8]subtype increased in China.In 2022,the G8P[8]subtype surpassed the G9P[8]subtype for the first time.In cases of diarrhea in infants younger than 5 years in Guangdong Province from 2021 to 2022,the RVA genotypes were diverse,the G9P[8]genotype significantly decreased,and the G8P[8]subtype became a dominant genotype.Continuous RVA genotype monitoring remains necessary to assess the risk of RVA-related disea-ses.
