Research progress in sialic acid-binding immunoglobulin-like lectins in bacterial infectious diseases
10.3969/j.issn.1002-2694.2024.00.109
- VernacularTitle:唾液酸结合免疫球蛋白样凝集素在细菌感染性疾病中的研究进展
- Author:
Yue-Yue HE
1
;
Yue-Jie ZHU
;
Yi-Chen FAN
;
Zheng-Wei YIN
;
Juan SHI
;
Feng-Bo ZHANG
;
Jian-Bing DING
Author Information
1. 新疆医科大学基础医学院,乌鲁木齐 830011
- Keywords:
Siglecs;
bacterial infection;
immune escape;
sialic acid(Sia)
- From:
Chinese Journal of Zoonoses
2024;40(8):790-795
- CountryChina
- Language:Chinese
-
Abstract:
Sialic acid-binding immunoglobulin-like lectins(Siglecs)are expressed on most white blood cells and play a key role in signal transduction of immune cells.Recent studies have shown that many bacterial pathogens regulate the host immune response through the interaction between sialic acid(Sia)and Siglecs,thereby influencing the occurrence and development of diseases.Understanding bacterial pathogenic mechanisms is essential to identify potential effective therapeutic targets and help manage bacterial infectious diseases.Herein,the structure,biological function,and research progress in Siglecs in bacterial in-fectious diseases are briefly reviewed.
