Research progress in the regulation of host antiviral signaling pathways by hepatitis E virus infection
10.3969/j.issn.1002-2694.2024.00.110
- VernacularTitle:戊型肝炎病毒感染调控宿主抗病毒信号通路的研究进展
- Author:
Guo ZHONG
1
;
Dong-Xue CHEN
;
Da-Qiao WEI
;
Fen HUANG
Author Information
1. 昆明理工大学医学院,昆明 650500
- Keywords:
hepatitis E virus;
innate immunity;
signal pathways;
immune escape;
interferon
- From:
Chinese Journal of Zoonoses
2024;40(8):782-789
- CountryChina
- Language:Chinese
-
Abstract:
Innate immunity is the first line of defense against viral infection.Hepatitis E virus(HEV)infection usually cau-ses acute self-limiting diseases in immunocompetent patients,but results in chronic infection in immunocompromised patients or pregnant people.After HEV infects host cells,pattern recognition receptors(PRRs)recognize the viral genome,thus indu-cing rapid activation of multiple antiviral signal pathways in the host immune system,and the expression of interferons(IFNs)and interferon stimulated genes(ISGs),and consequently inhibiting viral replication.To escape host antiviral responses,HEV encoded proteins regulate host antiviral signal pathways and subsequently inhibit antiviral responses,such as those involving cytokines or chemokines.The regulation of host signal pathways by HEV infection and the escape of HEV from host innate im-munity are reviewed herein.
