Clinical and laboratory characteristics of 32 patients with Listeria monocytogenes bacteremia
10.3969/j.issn.1002-2694.2024.00.104
- VernacularTitle:32例单增李斯特菌菌血症临床和实验室特征
- Author:
Ming YANG
1
;
Rui-Yan BAI
;
Jin-Ge TAI
;
Peng-Juan GUO
;
Ke DONG
Author Information
1. 空军军医大学唐都医院,西安 710038
- Keywords:
Listeria monocytogenes;
bacteremia;
clinical characteristics
- From:
Chinese Journal of Zoonoses
2024;40(7):652-655
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed at analyzing the clinical and laboratory characteristics of patients with Listeria monocyto-genes bacteremia,to provide evidence for its diagnosis and treatment.A retrospective analysis was conducted on the clinical data for patients with L.monocytogenes bacteremia at Tangdu Hospital between September 2012 and April 2022.The data included age,sex,underlying diseases,treatments,and prognosis.Changes in indicators such as white blood cell(WBC)count,mono-cyte percentage,neutrophil percentage,monocyte/neutrophil ratio(M/N),C-reactive protein(CRP),and procalcitonin before and after treatment were statistically analyzed.Among the 32 patients with L.monocytogenes bacteremia,the average age was 31.9 years,and three patients were older than 65 years.The incidence rate was highest in summer(11 patients,34.4％),fol-lowed by spring(9 patients,28.1％).A total of 24 patients(75.0％)had underlying diseases.After accurate diagnosis,the treatment plans of 29 patients were adjusted to target antibacterial therapy consisting primarily of penicillins(17 patients,53.1％)and carbapenems(12 patients,37.5％).After treatment,the levels of neutrophils,lymphocytes,and CRP were signifi-cantly lower than those before treatment(P＜0.05).A total of 29 patients(90.6％)improved and were discharged,one patient died,and two patients had poor prognosis.The primary risk factors for L.monocytogenes infection were autoimmune diseases,tumors,and pregnancy.Penicillin was the first choice effective empirical treatment for listeriosis.A clear diagnosis of the pathogen and appropriate choice of antibiotics were particularly important for the treatment of L.monocytogenes infection.
