Epidemiological and pathogenic analyses of three cases of imported Corynebacterium diphtheriae infection in Fujian Province
10.3969/j.issn.1002-2694.2024.00.081
- VernacularTitle:福建省3例输入性白喉棒状杆菌感染病例流行病学和病原学分析
- Author:
Qu-Wen LI
1
,
2
;
Xue-Chen LIANG
;
Ya-Dong GAO
;
Shun-Tai WENG
;
Yuan GAO
;
Zhu-Jun SHAO
Author Information
1. 福建省疾病预防控制中心(福建省人兽共患病研究重点实验室),福州 350012
2. 福建医科大学公共卫生学院专业教学实习基地,福州 350012
- Keywords:
Corynebacterium diphtheriae;
virulence gene;
cutaneous diphtheria
- From:
Chinese Journal of Zoonoses
2024;40(6):590-594,598
- CountryChina
- Language:Chinese
-
Abstract:
The epidemiology and etiology of three suspected cases of imported skin diphtheria infection in Fujian Province were investigated.Secretion samples of patients with skin damage were collected for isolation and culture of Corynebacterium diphtheriae.Biochemical identification and mass spectrum analysis of pure cultures of suspected C.diphtheriae were conduc-ted,the virulence-related genes,including diphtheria toxin reporter(dtxR),toxin A(toxA),and toxin B(toxB)were detec-ted,and multilocus sequence typing(MLST)was performed.All three cases had typical clinical manifestations of cutaneous diphtheria,and C.diphtheriae was isolated from the damaged skin.The virulence genes of two C.diphtheriae strains isolated from two cases were identified as dtxR(+),toxA(-),and toxB(-),and the MLST type was ST-703.The virulence genes of C.diphtheriae isolated from one case were identified as dtxR(+),toxA(+),toxB(+),and the MLST type was ST-248.There is an increased risk of diphtheria in Fujian Province.C.diphtheriae without diphtheria toxin genes can also cause skin diphtheria.
