Progress on the regulation of RhoA/ROCK signaling pathway in ischemic stroke
10.3969/j.issn.1672-5921.2024.10.009
- VernacularTitle:Ras同源基因家族蛋白A/Rho相关卷曲螺旋蛋白激酶信号通路调控缺血性卒中的研究进展
- Author:
Zhan ZHANG
1
;
Delong JIANG
;
Qingyan WANG
;
Pengqin WANG
Author Information
1. 110847 沈阳,辽宁中医药大学中医学院
- Keywords:
Ischemic stroke;
RhoA GTP-binding protein;
Rho-associated kinases;
RhoA/ROCK signaling pathway;
Inhibitor;
Review
- From:
Chinese Journal of Cerebrovascular Diseases
2024;21(10):700-707
- CountryChina
- Language:Chinese
-
Abstract:
Ras homolog gene family member A(RhoA)is a small GTPase protein.Rho-associated coiled-coil forming protein kinase(ROCK)can be activated during the occurrence and development of ischemic stroke.RhoA/ROCK signaling pathway is an important regulatory factor in the pathological process of ischemic stroke,and regulation of this signaling pathway has become a research focus in promoting neuronal recovery and improving cerebral ischemia/reperfusion injury after ischemic stroke.However,only Fasudil is currently available as a RhoA/ROCK inhibitor.The rest is still in the stage of research and development or clinical trials,and has broad research prospects.In this paper,the regulatory role and mechanism of RhoA/ROCK signaling pathway in ischemic stroke were analyzed,and the application of inhibitors and regulatory drugs were described,aiming to provide new ideas for the prevention and treatment of ischemic stroke.
