Recent advances in the role and regulatory mechanisms of aquaporin 4 in ischemic stroke
10.3969/j.issn.1672-5921.2024.10.008
- VernacularTitle:水通道蛋白4在缺血性卒中后的作用及调控机制研究进展
- Author:
Xiaomei WU
1
;
Linhui PENG
;
Kongping LI
;
Xialin ZUO
Author Information
1. 510260 广州医科大学附属第二医院神经科学研究所神经致病基因和离子通道教育部重点实验室
- Keywords:
Aquaporin 4;
Ischemic stroke;
Brain edema;
Blood-brain barrier;
Neuroglia;
Neuroinflammation;
Review
- From:
Chinese Journal of Cerebrovascular Diseases
2024;21(10):693-699
- CountryChina
- Language:Chinese
-
Abstract:
As the main water channel expressed in the brain,aquaporin 4(AQP4)has been implicated in the pathological process of ischemic stroke.After ischemic stroke,the expression,phosphorylation and polarity distribution of AQP4 are affected by the process of transcription and post-translational modification.The paper summarized the basic structure,physiological function,dynamic expression changes and mechanisms of AQP4 in this review,specifically discussing the role of AQP4 in cerebral edema,blood-brain barrier permeability and neuroinflammation after ischemic stroke,offering an up-to-date perspective on further effective therapeutic strategies for ischemic stroke.
