Advances in molecular mechanisms of carotid artery stenosis after radiotherapy
10.3969/j.issn.1672-5921.2024.09.008
- VernacularTitle:放射治疗后颈动脉狭窄的分子机制研究进展
- Author:
Xiao ZHANG
1
;
Shengyan CUI
;
Ran XU
;
Jiayao LI
;
Liqun JIAO
;
Tao WANG
Author Information
1. 100053 北京,首都医科大学宣武医院神经外科
- Keywords:
Carotid artery stenosis;
Radiotherapy;
Molecular mechanism;
Review
- From:
Chinese Journal of Cerebrovascular Diseases
2024;21(9):632-637
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,radiation therapy has become a cornerstone in the treatment of head and neck tumors,significantly improving patient survival rates.However,the issue of radiation-induced carotid artery stenosis has garnered increasing attention.Characterized by multiple,long-segment,and unstable lesions,radiation-induced carotid stenosis presents unique challenges that traditional therapeutic approaches struggle to address.This review systematically summarized the pathological features and underlying mechanisms of radiation-induced carotid stenosis,with a focus on the roles of endothelial cells,smooth muscle cells,and vasa vasorum damage.Future research directions and preventive strategies are also discussed.
