Research progress of cyclic AMP-activated exchange protein 1/RAS-related protein 1 signal pathway in the pathogenesis of cerebral ischemia-reperfusion injury

VernacularTitle:环腺苷酸激活交换蛋白1/RAS相关蛋白1信号通路在脑缺血-再灌注损伤发病机制中的研究进展
Author: Xue LYU ¹ ; Yihong SUN ; Zhipeng HUA ; Jianxin JIA
Author Information

1. 014010 内蒙古科技大学包头医学院研究生院
Keywords: Cerebral ischemia-reperfusion injury; Epac1/Rap1 signaling pathway; Pathogenesis; Review
From: Chinese Journal of Cerebrovascular Diseases 2024;21(8):552-558
CountryChina
Language:Chinese
Abstract: Cerebral ischemia-reperfusion injury(CIRI)is a serious complication caused by the recovery of blood flow in the affected brain tissue of patients with ischemic stroke.CIRI patients are often accompanied by neurological dysfunction,cognitive impairment,emotional disorders and other symptoms,which have a serious impact on daily life.At present,CIRI is easy to be diagnosed early,but there are relatively few related specific treatments.In this paper,the correlation between cyclic adenylate-activated exchange protein 1/RAS-related protein 1(Epac1/Rap1)signaling pathway and CIRI is reviewed,in order to provide new ideas for clinical treatment of CIRI patients.