Research progress of annexin A5 in diagnosis and treatment of ischemic stroke
10.3969/j.issn.1672-5921.2024.07.010
- VernacularTitle:膜联蛋白A5在缺血性卒中诊疗中的研究进展
- Author:
Zhanwei ZHU
1
;
Jiachen HE
;
Jiaqi GUO
;
Shuaili XU
;
Di WU
Author Information
1. 100053 北京,首都医科大学宣武医院中美神经科学研究所
- Keywords:
Ischemic stroke;
Annexin V;
Embolism;
Inflammation;
Review
- From:
Chinese Journal of Cerebrovascular Diseases
2024;21(7):499-504
- CountryChina
- Language:Chinese
-
Abstract:
Ischemic stroke is one of the important causes of disability and death among middle-aged and elderly people in China,and there are many complicated problems from diagnosis to treatment.At present,vascular recanalization has become the most important treatment for ischemic stroke.However,the prognosis of patients is still not ideal after vascular recanalization treatment alone.At the same time,the therapeutic effect of neuroprotective drugs targeting a single target is still not significant.Annexin A5 has many biological functions,such as anticoagulation,anti-inflammation,protection of neuron survival and so on,and can be used for neuroprotective therapy such as reducing reperfusion injury after cerebral vascular recanalization.Annexin A5 can be used in the diagnosis of stroke and the construction of targeted vectors because of its close binding with phosphatidylserine.The authors summarized the multiple functions of Annexin A5,and analyzes its possible effects on ischemic stroke,so as to provide reference for the follow-up study.
