A re-evaluation of the effectiveness of exercise interventions in patients with amyotrophic lateral sclerosis
10.3760/cma.j.cn115682-20240126-00513
- VernacularTitle:运动干预在肌萎缩侧索硬化患者中应用效果的系统评价再评价
- Author:
Jing SHAN
1
;
Yajie MIAO
;
Jia LIU
;
Jinju SUN
;
Xue MENG
;
Mengxue YANG
Author Information
1. 首都医科大学附属北京天坛医院护理部，北京 100070
- Keywords:
Amyotrophic lateral sclerosis;
Re-evaluation of systematic reviews;
Evidence-based nursing;
Exercise
- From:
Chinese Journal of Modern Nursing
2024;30(28):3852-3858
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To re-evaluate the effectiveness of exercise interventions in patients with amyotrophic lateral sclerosis (ALS) by conducting a systematic review and provide insights for the implementation and continuous improvement of exercise intervention strategies.Methods:A comprehensive search was conducted across databases, including CNKI, Wanfang, VIP, SinoMed, PubMed, Embase, Cochrane Library, Web of Science, CINAHL, Campbell Collaboration, and the Joanna Briggs Institute Evidence-Based Health Care Center Database. The search covered literature from the inception of the databases until December 19, 2023. Two researchers trained in evidence-based nursing independently screened the literature. The methodological quality of the included studies was assessed using the AMSTAR 2 tool, and the quality of evidence was graded using the GRADE system.Results:Eight systematic reviews were included. The AMSTAR 2 evaluation revealed one review of moderate quality, six of low quality, and one of very low quality. GRADE assessment of 33 outcome indicators showed that one piece of evidence was of moderate quality, 24 were of low quality, and eight were of very low quality.Conclusions:Exercise interventions may improve overall functional outcomes in ALS patients without exacerbating fatigue. However, due to the limitations in the quantity and quality of the included studies, further large-scale, high-quality randomized controlled trials are needed to verify the effects of exercise interventions in ALS patients.
