Effects of glucocorticoid stent implantation combined with nasal endoscopic surgery on nasal ventilation function and nasal mucosa recovery in patients with chronic sinusitis with nasal polyps
- VernacularTitle:糖皮质激素支架植入联合鼻内镜手术对慢性鼻窦炎伴鼻息肉患者鼻腔通气功能及鼻黏膜恢复的影响
- Author:
Yunfeng CHU
1
;
Lei HU
;
Liang SHAO
;
Dandan TAO
;
Xiaoting JIANG
Author Information
- Keywords: chronic sinusitis; nasal polyp; glucocorticoid stent; nasal endoscopic surgery; nasal ventilation function; eosinophil cationic protein(ECP); fibronectin(Fn); aquaporin-1(AQP-1)
- From: China Journal of Endoscopy 2024;30(7):24-30
- CountryChina
- Language:Chinese
- Abstract: Objective To analyze the effects of glucocorticoid stent implantation combined with nasal endoscopic surgery on nasal ventilation function and serum levels of eosinophil cationic protein(ECP),fibronectin(Fn)and aquaporin-1(AQP-1)in patients with chronic sinusitis with nasal polyp(CSwNP).Methods 60 patients with CSwNP from January 2022 to February 2023 were included in the study,and then they were divided into experimental group and control group,with 30 cases in each,using random number table method.The experimental group was treated with glucocorticoid stent implantation based on the original nasal endoscopic surgery,and the control group was treated with nasal endoscopic surgery,and both groups were treated until 12 weeks after surgery.The two groups of nasal symptoms,quality of life,nasal structure and ventilation function,serum levels of ECP,Fn,AQP-1,and adverse reactions were compared.Results Compared before the treatment,scores of nasal mucosal structure(Lund-Mackay scale),nasal symptom visual analogue scale(VAS)(including:nasal obstruction,runny nose,stuffy head,decreased sense of smell,nasal dryness/scab)and serum levels of ECP were decreased,distance from minimum nasal cross section to anterior nostril(DCAN)was shortened in two groups 12 weeks after treatment,and the experimental group was lower than the control group,the differences were statistically significant(P<0.05).Compared before the treatment,12 weeks after treatment,the nasal minimum cross-sectional area(NMCA),score of world health organization abbreviated quality of life(WHOQOL-100),nasal cavity volume(NCV),serum levels of Fn,AQP-1 were increased in two groups,and the experimental group was higher than the control group,the differences were statistically significant(P<0.05).During treatment,the incidence of adverse reactions was similar between the two groups(P>0.05).Conclusion Glucocorticoid stent implantation combined with nasal endoscopic surgery can control nasal symptoms in patients with CSwNP,improve nasal structure and ventilation function,regulate serum levels of ECP,Fn,AQP-1,and improve patients'quality of life.
