The therapeutic effect of retrograde intrarenal surgery on patients with renal calculus(diameter≤2 cm)and its impact on renal function and inflammation
- VernacularTitle:输尿管软镜碎石取石术治疗直径≤2cm的肾结石的疗效及对肾功能和炎症相关指标的影响
- Author:
Yibiao XIE
1
;
Xiaojian CUI
Author Information
- Keywords: renal calculus; retrograde intrarenal surgery(RIRS); supermini percutaneous nephrolithotomy(SMP); inflammatory markers; security
- From: China Journal of Endoscopy 2024;30(5):75-81
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the therapeutic effect of retrograde intrarenal surgery(RIRS)on patients with renal calculus(diameter≤2 cm)and its impact on renal function and inflammation.Methods From January 2020 to December 2022,194 patients with renal calculus(diameter≤2 cm)were divided into supermini percutaneous nephrolithotomy(SMP)group and RIRS group of 97 cases by random number talbe method.SMP group and RIRS group was treated with SMP and RIRS,all followed up for 1 week.Operation,renal function,stress response,inflammation-related indexes and complications were compared between the two groups.Results The time of indwelling of nephrostomy tube and hospital stay in RIRS groups were shorter than those in SMP groups,the intraoperative blood loss in RIRS groups was less than that in SMP group,the differences were statistically significant(P<0.05).The levels of serum cystatin C(Cys-C),serum creatinine(Scr)and unine neutrophil gelatinase-associated lipocalin(NGAL),kidney injury molecule-1(KIM-1)1 week after operation,and the serum reactive oxygen species(ROS),adrenaline(AD),noradrenaline(NA),adrenocorticotropic hormone(ACTH),lipid hydroperoxide(LPO),interleukin-6(IL-6),prostaglandin E2(PGE2)and hypersensitive C-reactive protein(hs-CRP)24 h after operation in the two groups were higher than those before surgery,and the RIRS group were lower(P<0.05).The overall complication rate during follow-up in the RIRS group was lower than that in SMP group(P<0.05).Conclusion Compared with SMP,RIRS in the treatment of renal calculus(diameter≤2 cm)has the advantages of less trauma,less bleeding,less renal damage,less postoperative stress,less inflammatory reaction and higher safety,which can promote postoperative recovery of patients.
