Macrophage polarization on transition from acute kidney injury to chronic kidney disease
10.3969/j.issn.1000-484X.2024.12.039
- VernacularTitle:巨噬细胞极化对急性肾损伤向慢性肾脏病转换的作用
- Author:
Shihan WANG
1
;
Shun WANG
Author Information
1. 新疆医科大学第一临床医学院(第一附属医院),乌鲁木齐 830054
- Keywords:
Acute kidney injury;
Chronic kidney diseases;
Macrophage polarization;
Inflammatory response
- From:
Chinese Journal of Immunology
2024;40(12):2685-2688,后插1-后插2
- CountryChina
- Language:Chinese
-
Abstract:
With development of times and progress of science,recent research supports hypothesis of acute kidney injury switching to chronic kidney disease in context of inflammation,and intensive study of macrophages shows that polarization of macro-phages plays a key role in regulating progression of inflammatory response.But clinical for kidney disease patients with macrophage mediated inflammation there is no clear unified treatment.This paper summaries latest progress of macrophage polarization path,new treatment targets of blocking acute kidney injury to chronic kidney disease,and future research should determine whether biologics,such as clusterin,can provide more opportunities for drug treatment of kidney inflammation and fibrosis.
