Myeloid-derived suppressor cells participate in regulation of development of autoimmune diseases
10.3969/j.issn.1000-484X.2024.12.036
- VernacularTitle:髓源性抑制细胞参与自身免疫性疾病发展的调控
- Author:
Piaotao CHENG
1
;
Shouhang GONG
;
Ping KONG
;
Chencheng LI
;
Caopei GUO
;
Jiachen PENG
Author Information
1. 遵义医科大学附属医院,遵义 563000
- Keywords:
Myeloid-derived suppressor cells;
Autoimmune disease;
Immunosuppression;
T cells
- From:
Chinese Journal of Immunology
2024;40(12):2666-2675
- CountryChina
- Language:Chinese
-
Abstract:
Myeloid-derived suppressor cells(MDSCs)are heterogeneous immature bone marrow cells with immunosuppres-sive effects.In recent years,with the in-depth study of the immunosuppressive activity of MDSCs,MDSCs have attracted much atten-tion in autoimmune diseases autoimmune disease(AD).In AD,MDSCs are significantly activated and amplified and regulate the im-mune response of the body through different mechanisms,thus promoting or inhibiting the development of the disease.Therefore,only by deepening the research on the specific role and mechanism of MDSCs in autoimmune diseases can we better clarify MDSCs and provide a positive role for the clinical transformation of the treatment of AD.This paper reviews the immunosuppressive mechanism of MDSCs and their roles in different AD.
