Intravitreal Injection of tPA and Gas for Submacular Hemorrhage Associated with Age-related Macular Degeneration.
10.3341/jkos.2008.49.2.267
- Author:
Jong Ho KIM
1
;
Jun Hyuk SON
;
Woo Hyok CHANG
Author Information
1. Department of Ophthalmology, Yeungnam University College of Medicine, Daegu, Koera. changwh@yumail.ac.kr
- Publication Type:Original Article
- Keywords:
Age-related macular degeneration;
Submacular hemorrhage;
Tissue plasminogen activator
- MeSH:
Choroidal Neovascularization;
Displacement (Psychology);
Eye;
Follow-Up Studies;
Hematoma;
Hemorrhage;
Humans;
Intravitreal Injections;
Macular Degeneration;
Outcome Assessment (Health Care);
Tissue Plasminogen Activator;
Visual Acuity
- From:Journal of the Korean Ophthalmological Society
2008;49(2):267-273
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To study the results of intravitreal tissue plasminogen activator (tPA) and expansile gas injection for the treatment of submacular hemorrhage in age-related macular degeneration (AMD). METHODS: Eleven consecutive patients (11 eyes) with submacular hemorrhage in AMD were included in this study. All patients were treated with intravitreal injections of tPA and C3F8 gas. Postoperatively, patients' follow-up period were at least 3 months. Outcome measures included early and final visual acuity, age, disc areas of hemorrhage, duration of symptoms, displacement of blood from the fovea, and final macular status. RESULTS: The maximum diameter of the hematoma ranged from 2 to 10 disc diameters. The mean duration of submacular hemorrhage was 7.5 days. Submacular blood was completely displaced in 7 patients (64%) and partially in four (36%). Best postoperative visual acuity improved in 7 eyes; in 6 eyes (55%), the improvement was two or more lines. Final visual acuity improved in 7 eyes (64%), remained stable in 2 eyes (18%), and worsened in 2 eyes (18%). Choroidal neovascularization positioned at subfovea in 7 eyes (64%) and juxtafovea in 4 eyes (36%). No significant difference was found between postoperative visual recovery and these factors. CONCLUSIONS: Our findings suggest that intravitreal tPA and expansile gas injection are safe and of useful for displacing hemorrhages secondary to age-related macular degeneration. Final visual acuity was limited by the underlying choroidal neovascularization of AMD.
