Common pathogenesis of gout and rheumatoid arthritis based on bioinformatics analysis
10.3969/j.issn.1000-484X.2024.12.003
- VernacularTitle:基于生物信息学分析探讨痛风与类风湿关节炎的共同发病机制
- Author:
Zichen SHAO
1
;
Huanan LI
;
Xiaoyun ZHANG
;
Weikang SUN
;
Qipeng YUAN
;
Jing LIU
;
Ling CHENG
Author Information
1. 江西中医药大学临床医学院,南昌 330004
- Keywords:
Gout;
Rheumatoid arthritis;
Bioinformatics;
Signaling pathway;
Biomarkers
- From:
Chinese Journal of Immunology
2024;40(12):2478-2483,中插1-中插2
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the common pathogenesis of gout and rheumatoid arthritis(RA)by bioinformatics analysis.Methods:Microarray expression profiles of peripheral blood mononuclear cells in gout and RA were obtained from the GEO public da-tabase.R language and other tools were used to re-annotates the chip,and then the differential genes(DEGs)of the two were screened and the intersection was taken.The protein-protein interaction(PPI)network and topology analysis of common differential genes(CO-DEGs)were constructed by STRING database and Cytoscape software(including CytoNCA plug-in).The HubGene was screened and validated by ROC curve.Finally,the DAVID online analysis tool was used to perform GO and KEGG functional enrichment analysis of HubGene.Results:There were 9 HubGene screened,they were TNF,RGS1,CD69,IL7R,DDX3X,SOCS3,IFIT1,IFIT3,CCL3.GO enrichment showed that HubGene was mainly involves the regulation of virus,STAT receptor signaling pathway and positive regu-lation of neuroinflammatory response.KEGG enrichment showed that HubGene was mainly involved in Toll like receptor signaling pathway,TNF signaling pathway,JAK-STAT signaling pathway,adipocytokine signaling pathway,RIG-Ⅰ-like receptor signaling pathway and osteoclast differentiation.Conclusion:Using bioinformatics analysis,nine HubGene and related signaling pathways in-volved in the pathogenesis of gout and RA have been identified,which may serve as novel biomarkers and potential targets.
