Research progress of MAVS in viruses evading host natural immunity
10.3969/j.issn.1000-484X.2024.11.036
- VernacularTitle:MAVS在病毒逃避宿主天然免疫中的研究进展
- Author:
Donglin BI
1
;
Xiaoli YANG
;
Dongliang YANG
;
Fangcheng LIU
;
Xiaowen ZHANG
;
Qiongyi LI
;
Jialin BAI
Author Information
1. 西北民族大学生物医学研究中心生物工程与技术国家民委重点实验室,兰州 730030
- Keywords:
Mitochondrial antiviral signaling proteins;
Innate immunity;
Viral infections;
Immune escape
- From:
Chinese Journal of Immunology
2024;40(11):2452-2457,2464
- CountryChina
- Language:Chinese
-
Abstract:
Innate immunity is the first line of the host cell defensing against viral infection,in which the pattern recognition re-ceptors(PRRs)such as Toll-like receptors(TLRs)and retinoic acid induces gene Ⅰ-like receptors(RLRs)play an important role.After virus infection,mitochondrial antiviral signaling protein(MAVS)in PRRs-mediated signaling pathway,which are of the com-mon linker molecule for downstream signal transmission,can receive signals transmitted by upstream TLR and RIG-Ⅰ,activate down-stream NF-κB and IRF3/7 signaling pathways leading to the activation of interferon(IFN)expression.Therefore MAVS acts as a bridge in the innate immune signaling pathway.More and more studies have shown that viruses have evolved a series of mechanism to escape the innate immune response over the long course of their evolution,and evaded the host's antiviral immune response by interfer-ing with multiple sites in the MAVS-mediated signaling pathway so as to complete its own replication and proliferation.In this paper,the role of MAVS in IFN-Ⅰ pathway and its latest research progress in the mechanism of anti-DNA viruses and anti-RNA viruses reac-tion are reviewed,providing theoretical basis for further studying the detailed mechanism of anti-virus of MAVS.
