Advances in regulation of macrophage polarization by prostaglandin E2
10.3969/j.issn.1000-484X.2024.11.034
- VernacularTitle:前列腺素E2对巨噬细胞极化的调节作用研究进展
- Author:
Wenbo LI
1
;
Cong WAN
Author Information
1. 哈尔滨医科大学附属第二医院心肌缺血教育部重点实验室,哈尔滨 150001
- Keywords:
Prostaglandin E2;
Macrophage;
Polarization;
Inflammatory diseases
- From:
Chinese Journal of Immunology
2024;40(11):2440-2443,2451
- CountryChina
- Language:Chinese
-
Abstract:
Prostaglandin E2(PGE2),an arachidonic acid metabolite,is a biologically active lipid small molecule,which was known as an inflammatory mediator previously.Macrophages are important cellular component of intrinsic immune system and the first line of defense against pathogenic invasion.Macrophages are highly plastic and can be simply divided into classically activated M1 type and alternative activated M2 type depending on their morphology and function.In healthy state,these two phenotypes of macro-phages are in a dynamic balance to maintain immune homeostasis;when body is stimulated by infection or inflammation,M1/M2 can be converted to each other,thus participating in disease onset and progression and influencing disease regression.It has been shown that PGE2 can regulate macrophage polarization in inflammatory diseases,involving complex mechanisms such as signaling pathways,metabolic processes,and miRNA regulatory networks.Therefore,this paper will briefly summarize mechanism of PGE2 regulation of macrophage polarization and effects of this regulation in inflammatory diseases.
